Goals from Neil Mellor and two from Chris Brown saw the Lilywhites to a victory on the seaside, with Adam Hammill socring for the home side.
Blackpool took the lead inside 10 minutes but a second half fight back for North End saw them to the three points.
PNE Starting XI: Lonergan, Jones, St. Ledger, Wayne Brown, Davidson, Sedgwick, McKenna, Chaplow, Wallace, Chris Brown, Mellor (Elliott 89).Subs Not Used: Mawene, Nicholson, Parkin, Neal.
Blackpool Starting XI: Rachubka, Barker, Evatt, Edwards, Camara, Taylor-Fletcher (Hendrie 74), Southern (McPhee 74), Jorgensen, Hammill, Burgess, Gow (Kabba 60).Subs Not Used: Broomes, Fox.
1. The home side score
Adam Hammill celevrates scoring the opening goal of the game. Photo: Bill Johnson
2. Lonergan gets it clear
Preston North End's Andy Lonergan goes for the ball against Blackpool at Bloomfield Road. Photo: Kevin McGuinness
3. The comeback begins...
The ball ripples the net as Chris Brown scores the equaliser for Preston North End against Blackpool at Bloomfield Road. Photo: Kevin McGuinness
4. Chris Brown celebrates with teammates
Chris Brown celebrates his equaliser with Callum Davidson and Ross Wallace. Photo: Kevin McGuinness